Readers of this News Blog will probably have seen a post on thrombolysis with alteplase for acute ischaemic stroke. A meta-analysis of individual data from 6,756 patients and nine RCTs has now reported. It concludes:
“Irrespective of age or stroke severity, and despite an increased risk of fatal intracranial haemorrhage during the first few days after treatment, alteplase significantly improves the overall odds of a good stroke outcome when delivered within 4·5 h of stroke onset, with earlier treatment associated with bigger proportional benefits.”
— Richard Lilford, CLAHRC WM Director
- Emberson J, Lees KR, Lyden P, et al. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet. 2014; 384(9958): 1929-35.