Migraine and Cardiovascular Disease

It is well established that migraine sufferers have an increased risk of both thrombotic and haemorrhagic stroke. A follow up of 115,541 women in the famous Nurses’ Health Study II, shows that the risk of myocardial infarction is also substantially increased, even after adjusting for risk factors such as obesity, in migraine sufferers. The authors think that migraine is a marker for some sort of endothelial malfunction.[1] The CLAHRC WM Director wondered if migraine sufferers have higher risk of preeclampsia, on the grounds that this is also thought to be an endotheliopathy. He is too late (again) – eight of ten studies in a systematic review found a positive association.[2]

— Richard Lilford, CLAHRC WM Director


  1. Kurth T, Winter AC, Eliasson AH, et al. Migraine and risk of cardiovascular disease in women: prospective cohort study. BMJ; 2016: 353: i2610.
  2. Adeney KL & Williams MA. Migraine Headaches and Preeclampsia: An Epidemiologic Review. Headache. 2006; 46(5): 794-803.

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