An example based on surgical technique for excision of cervical pre-cancer
It is well known that cervical pre-cancer is associated with increased risk of pre-term birth (with all that this entails), and that cervical treatment adds to the risk. A recent extensive meta-analysis of 70 observational studies with a control group of some sort showed that the more radical the procedure (in terms of tissue destroyed or removed), the greater the risk. This is important information for women who must balance the putative benefit of deeper margins against the documented risks to a subsequent pregnancy. Where possible (i.e. milder grade lesions) it may be advisable to delay treatment until after bearing children and, indeed, not to delay having children.
— Richard Lilford, CLAHRC WM Director
- Kyrgiou M, et al. Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis. BMJ. 2016; 354: i3633.