In a recent News Blog we showed how longitudinal studies could improve on cross-sectional epidemiological studies using alcohol-induced effects on lexical cognition, as our example.
Cross-sectional twin studies may also under-estimate inheritability of disorders, such as Autism Spectrum Disorder (ASD), because the control twin may be in a ‘yet to be diagnosed’ state. An interesting article in JAMA shows that the inheritability of ASD is much higher if the correct (longitudinal) method is used. All studies agree that familial environment has hardly any effect on the probability of ASD.
— Richard Lilford, CLAHRC WM Director
- Lilford RJ. Alcohol and its Effects. NIHR CLAHRC West Midlands News Blog. 18 August 2017.
- Sandin S, Lichtenstein P, Kuja-Halkola R, Hultman C, Larsson H, Reichenberg A. The Heritability of Autism Spectrum Disorder. JAMA. 2017; 318(12): 1182-4.