Coffee protects the liver against alcoholic cirrhosis  and there is previous animal and limited human evidence that it preserves cognition in older age. Data on this point have now emerged from ten years follow-up of nearly 6,500 enrolees in the Women’s Health Initiative Memory study. Women consuming above median caffeine intake experienced about a 25% reduction in dementia (p=0.04) or cognitive impairment (p=0.005). Surprise, surprise, caffeine modulates synaptic plasticity, discussed previously in your News Blog.[4-6]
— Richard Lilford, CLAHRC WM Director
- Kennedy OJ, Roderick P, Buchanan R, Fallowfield JA, Hayes PC, Parkes J. Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis. Ailment Pharmacol Ther. 2016; 43(5): 562-74.
- Shukitt-Hale B, Miller MG, Chu YF, Lyle BJ, Joseph JA. Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging. Age (Dordr). 2013; 35(6): 2183-92.
- Driscoll I, Shumaker SA, Snively BM, et al. Relationships Between Caffeine Intake and Risk for Probable Dementia or Global Cognitive Impairment: The Women’s Health Initiative Memory Study. J Gerontol A Biol Sci Med Sci. 2016; 71(12): 1596-1602.
- Lilford RJ. Psychiatry Comes of Age. NIHR CLAHRC West Midlands News Blog. March 11 2016.
- Lilford RJ. A Fascinating Account of the Opening Up of an Area of Scientific Enquiry. NIHR CLAHRC West Midlands News Blog. November 11 2016.
- Lilford RJ. Okay Then, There is a Fourth Period of Whole-Scale Synaptic Pruning in the Grey Matter of the Brain. NIHR CLAHRC West Midlands News Blog. January 13 2017.