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How Theories Inform our Work in Service Delivery Practice and Research

We have often written about theory in this News Blog.[1] [2] For instance, the ‘iron law’ of incentives – never use reward or sanction unless the manager concerned believes that they can influence the odds of success in reaching the required target.[3] [4] This law, sometimes called ‘expectancy theory’ was articulated by Victor Vroom back in 1964.[5] Here we review some of the theories that we have described, refined or enlarged over the last CLAHRC, and which we shall include among those we will pursue if we are successful in our Applied Research Collaborations (ARC) application. In each case we begin with the theory, then say how we have explicated it, and then describe how we plan to further develop theory through ongoing empirical work. Needless to say, our summaries are an impoverished simulacrum of the full articles:

  1. The theory of ‘hybrid managers’. It is well known that many professionals develop hybrid roles so that they toggle between their professional and managerial duties, and it is also known that tension can arise when the roles conflict. In our work we found that organisational factors can determine the extent to which nurses retain strong professional ethos when fulfilling managerial roles.[6] Simply put, the data seem to show that nurses working in more successful healthcare institutions tend to hew closer to their professional ethos than nurses in less successful units. It is reasonable to infer that an environment that can accommodate a strong professional orientation among hybrid managers is more likely to encompass the checks and balances conducive of safe care, than one that does not accommodate such a range of perspectives; most of us would choose to be treated in the environment where professional ethos is allowed a fair degree of expression. However, whether such a climate reflects better managers or a more difficult external environment is harder to discern. We now plan to examine this issue across many environments – for example, midwife hybrid managers balancing the need to expand choices of place of delivery with logistical limitations on doing so. Similarly, improving care for people with learning difficulties will require clinical managers to have freedom to innovate in order to improve services. Note that working with Warwick Business School enables us to locate our enquiries and theory development in the context of management in general, rather than just the management of health services. For example, the above study of nurse managers encompasses tax inspectors who now have to balance their traditional role in enforcing the tax code with one of helping the likes of us to make accurate declarations.
  2. Hybrid managers as knowledge brokers. Hybrid managers, it is known, act as a conduit between senior managers and frontline professionals, in mediating adoption of effective practice – i.e. knowledge brokering. It is also known that effecting change means overcoming structural, social and motivational barriers. The task of implementing state-of-the-art care practices is a delicate one and, prior to our research, the social dynamic of effecting change was poorly understood. In particular, the CLAHRC WM team wanted to study the role of status and perceived legitimacy in facilitating or inhibiting the knowledge brokers task. We found that hierarchies are critically important – safe care is more than following rules, but requires a degree of initiative (sometimes called discretional energy) by multiple actors across the hierarchy.[7] Nurses were often severely inhibited in using such personal initiative. The attitude of more senior staff is thus crucial in permitting, indeed encouraging, the use of initiative within a broader system of checks and balances. If the hierarchy within nursing is a barrier to progress, then that between doctors and nurses is a much bigger obstacle to uptake of knowledge. Moreover, there was also evidence of a difference barrier across different medical specialities with clinicians at the most action-oriented end of the spectrum (such as surgeons) showing lower levels of team-working than those with more reflective daily tasks (such as geriatricians). The work pointed towards the effectiveness of creating opportunities for purposeful interaction across these various types of hierarchical barriers – what the researchers called “dyadic relationships between hybrid middle managers with clinical governance responsibility and doctors through engagement and participation in medical-oriented meetings”; Elinor Ostrom would call this opportunities for ‘cheap talk’.[8] This work is crucial for laying the foundation for our work on the integration of care covering management of patients at the acute hospital / ambulance / community interface; care of patients with multiple diseases; care of the elderly; and the care of people with rare diseases, to mention but a few. Clearly, such opportunities for structured interaction are only parts of the story, and other factors that have been shown to be important (e.g. job design, performance management, education, patient empowerment, and data sharing) must be included in service improvement initiatives.
  3. Logics. Our third example concerns the unwritten assumptions that underpin what a person should do in their domain of work, and why they do it – so called ‘logics’. In a place like a hospital or university, many professions must co-exist, yet each will have a different ‘logic’. This idea applies across society, but CLAHRC WM investigator Graeme Currie wanted to examine how the professional logic and policy logic interact in a hospital setting.[9] The background to this study is the finding that policy logic has constrained and limited professional logic over the last few decades – doctors are no longer in charge of performance improvement, the management of waiting lists, etc. The researchers used the introduction of a new evidence-based, multi-component guideline as a lens through which to explore the interactions of different ‘logics’ in hospital practice. The implementation of a multi-component guideline is not a simple thing, and some intuitive cost-benefit calculations could justify, at least intellectually, massaging some aspects of the guideline to fit management practices rather than the reverse. However, the way this played out was not the same across contexts. As before, doctors were generally (but not invariably) less amenable to change than nurse practitioners with managerial responsibility. This study, published in a premier management journal,[9] identifies contingencies that will provide depth to our evaluations of different ways to reshape services. We will build on these insights when we examine a proposed service to use Patient Reported Outcome Measures, rather than simply elapsed time, to determine when patients should be seen in the outpatient department. An understanding of ‘logics’ is likely to come into play when we empower community and ambulance staff to elicit patient preferences and respect them even when to do so flies in the face of guidelines. At the level of the system, change is best viewed as an institutional problem of professional power and policy, around which change needs to orientate. It is not that systems and organisations can’t be changed, but subtle tactics and work may be required.[10] [11]
  4. Health care organisations viewed as political grouping and the need to do ‘political work’ when implementing interventions. Trish Greenhalgh has recently provided an evidence-based framework which unpicks reasons why IT implementations so often disappoint.[12] She points out that managers consistently underestimate the size of the task and the sheer difficulty of implementing IT systems so that they reach even some of their potential. Likewise, work conducted under an NIHR Programme grant that developed out of CLAHRC WM showed how new IT systems could introduce serious new hazards.[13] One of the methods to avoid failure in any large initiative, such as a large IT system, comes from a study of Italian hospitals conducted by the CLAHRC WM team,[14] advocating an iterative process, time and careful preparation of the ground by doing ‘political work’ to win hearts and minds and adapt interventions to context.[15] This type of approach will be critical to the development of complex interventions, such as those widening access to homebirth, and integrating patient feedback (including Patient Reported Outcome Measures) into patient care pathways.
  5. Absorptive capacity. Many CLAHRCs have relied on a knowledge brokering model to underpin translation of research, through which key individuals ensure knowledge gets to the right people at the right time to benefit patient care.[16] However, such an approach may have a limited effect and we need to consider how organisations and systems can be developed to ensure the efforts of knowledge brokers are leveraged and evidence informs patient care more widely. This is a matter of developing organisation and system ‘absorptive capacity’. Many of the implementation studies under our current CLAHRC have sought to develop co-ordination capability of organisations and systems to translate evidence into practice. For example, public and patient involvement, GP involvement, better business intelligence processes and structures is highlighted as ensuring clinical commissioning groups make evidence-informed decisions.[17] We have taken our work further to develop a ‘tool’ to assess the Absorptive Capacity of organisations.[18]

In this short review we have described how theoretical work, based on the development and evaluation of service interventions, can help understand the reasons why an intervention may succeed or fail, and how this may vary from place to place. Increasingly we are applying Elinor Ostrom’s work on collaboration between managers when the incentives are not aligned to the problems of integrated care in the NHS.[19] Our work represents successful collaboration between management and medical schools and, indeed, a difference in ‘logics’ between these organisations. This collaboration has taken time to mature, as have those between the services and academia more broadly. The essential point is that consideration of wider organisational and systems context will prove crucial to our efforts to continue broadening, accelerating and deepening translation of evidence into practice in our proposed ARC.

— Richard Lilford, CLAHRC WM Director

— Graeme Currie, Professor of Public Management, CLAHRC WM Deputy Director

References:

  1. Lilford RJ. A Theory of Everything! Towards a Unifying Framework for Psychological and Organisational Change Models. NIHR CLAHRC West Midlands News Blog. 28 August 2015.
  2. Lilford RJ. Demystifying Theory. NIHR CLAHRC West Midlands News Blog. 10 April 2015.
  3. Lilford RJ. Financial Incentives for Providers of Health Care: The Baggage Handler and the Intensive Care Physician. NIHR CLAHRC West Midlands News Blog. 25 July 2015.
  4. Lilford RJ. Two Things to Remember About Human Nature When Designing Incentives. NIHR CLAHRC West Midlands News Blog. 27 January 2017.
  5. Vroom VH. Work and motivation. Oxford, England: Wiley. 1964.
  6. Croft C, Currie G, Lockett A. The impact of emotionally important social identities on the construction of managerial leader identity: A challenge for nurses in the English NHS. Organ Stud. 2015; 36(1): 113-31.
  7. Currie G, Burgess N, Hayton JC. HR Practices and Knowledge Brokering by Hybrid Middle Managers in Hospital Settings: The Influence of Professional Hierarchy. Hum Res Manage. 2015; 54(5): 793-812.
  8. Lilford RJ. Polycentric Organisations. NIHR CLAHRC West Midlands News Blog. 25 July 2014.
  9. Currie G & Spyridonidis D. Interpretation of Multiple Institutional Logics on the Ground: Actors’ Position, their Agency and Situational Constraints in Professionalized Contexts. Organ Stud. 2016; 37(1): 77-97.
  10. Currie G, Lockett A, Finn R, Martin G, Waring J. Institutional work to maintain professional power: Recreating the model of medical professionalism. Organ Stud. 2012; 33(7): 937-62.
  11. Lockett A, Currie G, Waring J, Finn R, Martin G. The influence of social position on sensemaking about organizational change. Acad Manage J. 2014; 57(4): 1102-29.
  12. Lilford RJ. New Framework to Guide the Evaluation of Technology-Supported Services. NIHR CLAHRC West Midlands News Blog. 12 January 2018.
  13. Cresswell KM, Mozaffar H, Lee L, Williams R, Sheikh A. W. Workarounds to hospital electronic prescribing systems: a qualitative study in English hospitals. BMJ Qual Saf. 2017; 26: 542-51.
  14. Radaelli G, Currie G, Frattini F, Lettieri E. The Role of Managers in Enacting Two-Step Institutional Work for Radical Innovation in Professional Organizations. J Prod Innov Manag, 2017; 34(4): 450-70.
  15. Lilford RJ. Implementation Science at the Crossroads. BMJ Qual Saf. 2017; 27: 331-2.
  16. Rowley E, Morriss R, Currie G, Schneider J. Research into practice: Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for Nottinghamshire, Derbyshire and Lincolnshire (NDL). Implement Sci. 2012; 7:
  17. Croft C & Currie G. ‘Enhancing absorptive capacity of healthcare organizations: The case of commissioning service interventions to avoid undesirable older people’s admissions to hospitals’. In: Swan J, Nicolini D, et al., Knowledge Mobilization in Healthcare. Oxford: Oxford University Press; 2016.
  18. Currie G, Croft C, Chen Y, Kiefer T, Staniszewska S, Lilford RJ. The capacity of health service commissioners to use evidence: a case study. Health Serv Del Res. 2018; 6(12).
  19. Lilford RJ. Evaluating Interventions to Improve the Integration of Care (Among Multiple Providers and Across Multiple Sites). NIHR CLAHRC West Midlands News Blog. 10 February 2017.
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Low-Tech Solution to a Devastating Infection

What do you do when you finish your bottle of shampoo? Throw it straight in the recycling bin? Turn it into a child’s space rocket? Well, Dr Mohamad Chisti became inspired to invent a treatment for pneumonia.

Globally more than 920,000 children died from pneumonia in 2015, accounting for around 16% of all deaths in under-fives.[1] However, this rate is far higher in low-income countries, such as Bangladesh where the figure is 28%.[2] This is partially due to the greater amount of malnourishment – pneumonia results in inflammation of the alveoli in the lungs, resulting in breathlessness and difficulty breathing – malnourished children do not have the energy required to breath in enough oxygen. The standard treatment listed in World Health Organization guidelines is to deliver ‘low-flow’ oxygen through a face mask or tubes near the nostrils, but this still requires a lot of effort to breathe. Whilst visiting Australia Dr Chisti was shown a bubble-CPAP ventilator for premature babies. This type of ventilator passes exhaled breath through water, which forms bubbles that push fresh air into the lungs and thus makes breathing easier. However, the device is prohibitively expensive for many hospitals in low-income countries. When Dr Chisti spotted a discarded shampoo bottle he realised it could be possible to recreate such a ventilator at a fraction of the cost.[3] Results of a trial to assess the efficacy of bubble-CPAP for children with pneumonia were published in the Lancet in 2015, with positive results,[4] and since then the mortality rate at Dhaka Hospital where the device is used routinely has significantly decreased, as have associated costs.[5] Further trials are starting to be carried out in other hospitals.

— Peter Chilton, Research Fellow

References:

  1. UNICEF. Pneumonia. 2018.
  2. International Centre for Diarrhoeal Disease Research, Bangladesh. Pneumonia and other respiratory diseases. 2018.
  3. Duke T. CPAP: a guide for clinicians in developing countries. Paediatr Int Child Health. 2013; 34(1): 3-11.
  4. Chisti MJ, Salam MA, Smith JH, et al. Bubble continuous positive airway pressure for children with severe pneumonia and hypoxaemia in Bangladesh: an open, randomised controlled trial. Lancet. 2015; 386: 1057-65.
  5. The Economist. How a shampoo bottle is saving young lives. The Economist. 6 September 2018.

Electronic Health Records and Mortality Rate

In a number of our previous blogs we have looked at the impact of electronic health records,[1-3] and now we add another.[4] In a paper recently published in Health Affairs the authors found that adoption of electronic health records was associated with an improvement in thirty-day mortality rates. Although the mortality rates increased when hospitals initially introduced the system (0.11 percentage points per function [such as radiology reports, laboratory reports, radiology images, medication prescribing, etc.] that was adopted), this improved over time (presumably as staff become more familiar, and were able to integrate the system into their work), and eventually mortality rates had decreased by 0.09% per year, per function adopted. Adding new functions during the study period saw further improvements with a decrease of 0.21% per year, per function. These improvements were greatest in smaller hospitals and those that were not teaching hospitals – perhaps because such hospitals have more opportunity for improvement as they are less likely to have engaged other initiatives; or they may have lacked resources to implement other improvement initiatives.

— Peter Chilton, Research Fellow

References:

  1. Lilford RJ. Going Digital – The Electronic Patient Record. NIHR CLAHRC West Midlands News Blog. 6 May 2016.
  2. Lilford RJ. Electronic Health Record System and Adverse Outcomes. NIHR CLAHRC West Midlands News Blog. 28 October 2016.
  3. Lilford RJ. If You Have Time for Only One Article. NIHR CLAHRC West Midlands News Blog. 24 August 2018.
  4. Lin SC, Jha AK, Adler-Milstein J. Electronic Health Records Associated With Lower Hospital Mortality After Systems Ha­ve Time To Mature. Health Aff. 2018;37(7).

An Aspirin A Day to Keep the Doctor Away?

Many healthy elderly people take a daily dose of aspirin as a preventive measure, often in order to lower their risk of cardiovascular illness. But is this practice beneficial? A series of three analyses in the New England Journal of Medicine suggests not.[1-3] The ASPREE study looked at more than 19,000 healthy elderly individuals, randomly assigning half to receive a daily aspirin, and half to receive a placebo, and followed them for a median of 4.7 years. There was no significant difference between the groups with regards to disability-free survival (p=0.79),[1] or risk of cardiovascular disease,[2] but there was a higher rate of major haemorrhage seen in those taking aspirin (hazard ratio 1.38, 95% CI 1.18-1.62).[1] Further, the authors found that the risk of any-cause mortality was 12.7 (per 1,000 person-years) in those taking aspirin, compared to 11.1 in those taking placebo – a hazard ratio of 1.14 (95% CI 1.01-1.29).[3] The main cause of the excess mortality was cancer-related death: 3.1% of those taking aspirin vs. 2.3% of those taking placebo (hazard ratio 1.31, 95% CI, 1.10-1.56).

Previous trials of aspirin have shown a protective effect with regards to cancer-related death,[4] suggesting these results should be interpreted cautiously, and that longer term follow-up could be informative.

It is important to note that these were healthy individuals, with no history of cardiovascular disease, dementia or disability, and who had not been previously prescribed aspirin by their doctor.

— Peter Chilton, Research Fellow

References:

  1. McNeill JJ, Woods RL, Nelson MR, et al. Effect of Aspirin on Disability-free Survival in the Healthy Elderly. New Engl J Med. 2018.
  2. McNeill JJ, Wolfe R, Woods RL, et al. Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly. New Engl J Med. 2018.
  3. McNeil JJ, Nelson MR, Woods RL, et al. Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. New Engl J Med. 2018.
  4. Rothwell PM, Fowkes FGR, Belch JFF, Ogawa H, Warlow CP, Meade TW. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet. 2011; 377: 31-41.

Myopia is Caused Partially by Long Hours of Study

It is well known that short-sightedness, or myopia, is associated with the intensity and duration of education.[1] But is this cause and effect? A Mendelian randomisation study, beloved of the CLAHRC WM Director, finds strong evidence for a causal explanation.[2] Using this form of analysis there is a statistically strong association between genes that predispose  to long duration of education and myopia. The reverse does not apply; genes associated with myopia are not associated with duration of education. Together, these findings argue against reverse causality.

That said, the effect, although statistically highly significant, is not large. Genes associated with longer education explain only 7% of the variance in the incidence of myopia.  However, they do suggest that something associated with education is causal of myopia, and it is probable that the intensity of book work is also important. The incidence of myopia has risen dramatically in recent years, especially in China, where both the intensity and duration of education have increased over the last generation. Myopia can sometimes lead to blindness. These results are therefore very important.

It seems that children should have a balanced life between looking at books and screens, versus playing in the outdoors. In fact, there are probably other, even stronger, arguments for such a lifestyle prescription.

— Richard Lilford, CLAHRC WM Director

References:

  1. Gwiazda J, Deng L, Dias L, et al. Association of Education and Occupation with Myopia in COMET Parents. Optom Vis Sci. 2011; 88(9): 1045-53.
  2. Mountjoy E, Davies NM, Plotnikov D, et al. Education and myopia: assessing the direction of causality by mendelian randomisation. BMJ. 2018; 361: k2022.

Changes in Mealtimes Leading to Eating Less

People have long looked for a method of dieting that is effective and easy to undertake. A recent pilot study in the Journal of Nutritional Sciences may offer a new alternative.[1] For ten weeks participants were required to both delay their usual breakfast time and bring forward their evening meal time by an hour and a half – there were no other restrictions on what food they could consume, or what exercises they needed to do. When compared to a control group they found that the participants in the intervention group reduced their daily energy intake (p=0.019), with an associated reduction in adipose levels (p=0.047). Further, there was also a significant difference in fasting glucose levels, though the authors note that this was mainly due to an increase in control participants compared to baseline. Questionnaire results suggest that the reduction in energy intake may have been due to less time for snacking, and/or still feeling full from the previous meal. Unfortunately the majority of participants found that the restrictions were too severe, impacting on their social and family life, and did not believe they could continue past the end of the study.

Although this was only a very small study of 13 participants it shows a potential opportunity for future research.

— Peter Chilton, Research Fellow

Reference:

  1. Antoni R, Robertson TM, Robertson MD, Johnston JD. A pilot feasibility study exploring the effects of a moderate time-restricted feeding intervention on energy intake, adiposity and metabolic physiology in free-living human subjects. J Nutri Sci. 2018;7:e22.

Another Paper on Applied Use of Behavioural Science Published in the Journal ‘Science’

We recently reported an article from Science on an educational intervention to improve the quality of clinical care delivered by informal providers in rural settings in India.[1] A further article has now been published in the journal describing how principles derived from behavioural theory were used to influence physician prescribing behaviour.[2] The prescribing practice targeted in the article concerned inappropriate prescribing of narcotics for chronic, non-cancer, pain. The participants, who did not consent to the study, were groups (clusters) of 861 clinicians who had prescribed opiates to someone who then died of an opioid overdose. Since more than one clinician prescribes to a given decedent (person who has died) the clinicians were clustered by the person for whom they had prescribed and who had then died of complications of opioid use. The clusters were randomised into two groups (84 intervention and 86 controls). The intervention group received a letter, supportive in tone, from the ‘medical examiner’ who is a person of authority dealing with unexpected deaths (a type of coroner). The letter described the problem and reiterated official advice.

The headline result was a highly significant decrease of nearly 10% in narcotic prescriptions in a difference-in-difference analysis across the clusters. In addition, a smaller proportion of people were started on narcotics, and a lower proportion on high dose prescriptions were issued, in the intervention group. In your next News Blog we will describe a CLAHRC WM trial based on similar behavioural principles.

— Richard Lilford, CLAHRC WM Director

References:

  1. Lilford RJ. A Fascinating Trial of an Educational Intervention to Improve the Quality of Care in Rural India. NIHR CLAHRC West Midlands News Blog. 4 May 2018.
  2. Doctor JN, Nguyen A, Lev R, et al. Opioid prescribing decreases after learning of a patient’s fatal overdose. Science. 2018; 361: 588-90.

People Designated as Allergic to Penicillin Have an Increased Incidence of Clostridium Difficile Diarrhoea

This hypothesis was tested out by a group of researchers from Harvard using the THIN Database from England [1]; a nice example of the merits of making the data collected in one country available to researchers in another.

The hypothesis that these investigators are examining is obvious: they want to see whether the substitution of broad spectrum antibiotics for penicillin and its analogues, leads to a detectable increase in Clostridium difficile diarrhoea. This is an important investigation, since only 5% of people labelled as allergic, have any real risk of an immediate reaction to penicillin.

This study was based on over 64,000 people with putative penicillin allergy and nearly 200,000 matched comparators. Over a mean of six years of follow up, an approximately 70% increase in risk of C. difficile was observed among patients labelled allergic to penicillin. The authors suggest routine testing for penicillin allergy, but I think this would be logistically hard to achieve, and recommend more careful history taking when making the original diagnosis. Other measures to reduce the incidence of Clostridium difficile diarrhoea, such as more circumspect prescription of fluoroquinolones, should also be pursued.

— Richard Lilford, CLAHRC WM Director

Reference:

  1. Blumenthal KG, Lu N, Zhang Y, et al. Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. BMJ. 2018; 361: k2400.

Embolisation of the Hypertrophic Prostate: a Good Idea?

The above BMJ article [1] caught my eye because a dear friend of mine suffered a severe side effect following embolisation of his prostate gland. The study was an open label, randomised trial from Switzerland.

The study calls itself a non-inferiority trial. However, with a total of only 103 participants, it is insufficiently powered to exclude serious side effects or, for that matter, to detect worthwhile benefits. In any event there was no difference in symptom scores after 12 weeks, but the point estimate favoured the traditional transurethral resection of the prostate over embolisation. No difference in clinical symptoms was noted statistically, but the point estimate favoured surgery and follow-up was for three months only. There was no real difference in side effects, but dynamic studies showed a greater return towards normal in the surgery group.

In my humble opinion, this trial is completely inadequate to drive a change in practice and I recommend further, much larger, RCTs with longer follow-up.

— Richard Lilford, CLAHRC WM Director

Reference:

  1. Abt D, Hechelhammer L, Müllhaupt G, et al. Comparison of prostatic artery embolisation (PAE) versus transurethral resection of the prostate (TURP) for benign prostatic hyperplasia: randomised, open label, non-inferiority trial. BMJ. 2018; 361: k2338.

An Article about Citizen Science Published in Science

News blog readers are referred to the above thoughtful article,[1] which discusses the rise in citizen science, and the policy response in the USA.

The article covers three crucial areas: intellectual property, research integrity, and protection of the citizen scientist. Potential problems are identified and sensible solutions offered. However, the article is clearly not concerned with clinical or health services research. Here, additional issues of confidentiality and protection of patients and the public come into the frame. This is a topic which has been covered in a recent issue of your News Blog.[2]

— Richard Lilford, CLAHRC WM Director

References:

  1. Guerrini CJ, Majumder MA, Lewellyn MJ, McGuire AL. Citizen Science, Public Policy. Science. 2018; 361(6398): 134-6.
  2. Lilford RJ. Patient and Public Involvement: Direct Involvement of Patient Representatives in Data Collection. NIHR CLAHRC West Midlands News Blog. 4 August 2017.